李晔|副教授

树木细胞生物学、分子模拟、纳米材料-植物相互作用,细胞壁,纳米基因载体,纳米农药。
近年来,依托主持的国家自然科学基金等项目的支持,基于国际学术前沿,结合分子模拟技术、材料学、细胞生物学等多学科交叉手段,主要开展纳米材料作为药物/基因载体在植物中的跨细胞转运的机理研究。目前本人以第一或通讯作者在《Biomaterials》、《Science Bulletin》、《Nanoscale》、《Soft Matter》、《Nanoimpact》、《Nanotechnology》等SCI学术期刊发表研究性论文17余篇,累计影响因子:150+,多篇论文选入期刊的封面文章,参编著作1部。
2015/07-至今:ky开云手机版,细胞生物学学科,讲师、副教授、博士生导师、“林木分子设计育种”北京市高精尖创新中心青年研究员、“北林学者”
2010/08-2015/06:北京化工大学,博士 (硕博连读)
1. 国家自然科学基金青年科学基金项目“拟南芥中网格蛋白介导的选择性胞吞的调控机制” (2017/01-2019/12), 22万,主持
2. 北京林业大学科技创新计划项目“壳聚糖复合单壁碳纳米管作为林木基因载体的应用及跨细胞转运的分子机制研究” (2021/06-2022/12), 12万,主持
3. 北京林业大学科技创新计划项目“网格蛋白介导的内吞机理的研究” (2015/10-2017/10 ), 7万,主持
4. 国家自然科学基金面上项目“类水滑石纳米材料作为植物细胞跨膜载体的应用研究”(2017/01-2020/12), 62 万,参与
5. 国家重点研发计划,活细胞大景深纳米尺度单分子成像与示踪功能模块研制(2022/01-2026/10),150万,在研、参与(分配经费:20万元)
1. 2024年:指导本科生参加第十届北京市大学生生物学竞赛 北京市级 三等奖
2. 2023年:指导本科生参加第八届全国大学生生命科学竞赛 国家级 全国二等奖
3. 2023年:指导本科生参加第九届全国大学生生命科学竞赛 省部级 北京市一等奖
4. 2023年:教学改革与研究论文 优秀奖
5. 2022年:教学改革与研究论文 三等奖
6. 2022年:教学改革与研究论文 优秀奖
7. 2020年: 北京林业大学本科课程优秀教案 二等奖
8. 2020年:北京林业大学教育教学研究论文 优秀奖
9. 2019年:北京林业大学教学基本功比赛 实践类 三等奖
10. 2017年:第六届“北京林业大学优秀青年学术论文奖” 二等奖
11. 2014年:博士研究生国家奖学金
12. 2012年:硕士研究生国家奖学金
1. Ye Li(李晔) *, Yezhuo Zhang, Zhun Zhang, Man Zhang, Xinhui Niu, Xinyi Mao, Tongtao Yue, Xianren Zhang*. Clathrin-Mediated Endocytosis of Multiple Nanoparticles Tends to Be Less Cooperative: A Computational Study. The Journal of Physical Chemistry B, 2024, 128: 9785-9797(SCI, IF=3.607)
2. Lina Fu#, Ye Li(李晔) #, Xinlin Zhang, Jihong Cui, Xuanting Zhao, Jiandong Wang, Quan zhou, Litao Wang, Yujie Fu*. Targeted recognition and enhanced biotransformation of phytochemicals by a dual-functional cellulose-based hydrogel bioreactor. International Journal of Biological Macromolecules, 2024, 281, 136271.(SCI, IF= 7.79)
3. Ye Li(李晔) *, Zhun Zhang, Yezhuo Zhang, Jingcheng Hu, Yujie Fu*. Design Principles for Smart Linear Polymer Ligand Carriers with Efficient Transcellular Transport Capabilities. International Journal of Molecular Sciences, 2024, 25: 6826(SCI, IF=4.9)
4. Zhun Zhang, Yezhuo Zhang, Zhendan Liu, Ye Li(李晔)*. Role of Different Dimensions of Skeleton Proteins in the Endocytosis of Various Shaped Nanoparticles. Acs Applied Nano Materials, 2024,7(23):27185-27196. (SCI,IF=5.3)
5. Ye Li (李晔) *,Man Zhang, Yezhuo Zhang,Xinhui Niu, Zhendan Liu,Tongtao Yue, Wen Zhang. A computational study of the influence of nanoparticle shape on clathrin-mediated endocytosis. Journal of Materials Chemistry B, 2023, 11:6319. (SCI, IF = 7.0)
6. Ye Li(李晔)*, Man Zhang, Xinhui Niu, Tongtao Yue*. Selective membrane wrapping on differently sized nanoparticles regulated by clathrin assembly: A computational model Colloids and Surfaces B: Biointerfaces, 2022, 214:112467. (SCI, IF = 5.268)
7. Ye Li (李晔)*, Xinhui Niu, Lingzhi Li, Xianren Zhang, Kai Yang* Tongtao Yue*. Size, geometry and mobility of protein assemblage regulate the kinetics of membrane wrapping on nanoparticles. Journal of Molecular Liquids, 2021, 333:115990. (SCI, IF = 5.065)
8. Ye Li (李晔)*, Zengshuai Yan, Jianwei Xiao, Tongtao Yue*. DNA-conjugated layered double hydroxides penetrating into a plasma membrane: Layer size, thickness and DNA grafting density matter. Nanoimpact, 2020, 100222. (SCI, IF = 5.316 )
9. Ye Li (李晔), Xianren Zhang, Jinxin Lin, Ruili Li*, Tongtao Yue *. Extracting lipid vesicles from plasma membranes via self-assembly of clathrin-inspired scaffolding nanoparticles. Colloids and Surfaces B: Biointerfaces, 2019, 176:39-248. (SCI, IF = 5.268)
10. Ye Li (李晔)# *, Wenlong Bao#, Hongyang Wu, Junya Wang, Yu Zhang, Yinglang Wan, Dapeng Cao, Dermot O’Hare, Qiang Wang*. Delaminated layered double hydroxide delivers DNA molecules as sandwich nanostructure into cells via a non-endocytic pathway. Science Bulletin, 2017, 62: 686-692. (SCI, IF = 18.9)
11. Ye Li (李晔), Bing Yuan, Kai Yang*, Xianren Zhang, Bing Yan, Dapeng Cao*. Counterintuitive cooperative endocytosis of like-charged nanoparticles in cellular internalization: computer simulation and experiment. Nanotechnology, 2017, 28. ( SCI, IF = 3.440)
12. Ye Li (李晔), Diwen Feng, Xianren Zhang*, Dapeng Cao*. Design strategy of cell-penetrating copolymers for high efficient drug delivery. Biomaterials, 2015, 52:171-179. (SCI Top, IF = 15.8)
13. Ye Li (李晔), Xianren Zhang*, Dapeng Cao*. Tailoring nanoparticle hardness to control endocytosis for drug delivery. Nanoscale, 2015, 7: 2758 - 2769 (SCI Top, IF= 6.973)
14. Ye Li (李晔), Xianren Zhang*, Dapeng Cao*. Spontaneous penetration mechanism of patterned nanoparticles across a biomembrane. Soft Matter, 2014, 10: 6844-6856. (SCI Top, IF=4.151)
15. Ye Li (李晔), Xianren Zhang*, Dapeng Cao*. The role of shape complementarity in the protein-protein interaction. Scientific Report, 2013, 3: 3271. (SCI, IF=5.078)
16. Ye Li (李晔), Xianren Zhang*, Dapeng Cao*. Self-assembly of patterned nanoparticle on cellular membrnaes: effect of charge distribution. The Journal of Physical Chemistry B, 2013, 117: 6733-6740.(SCI, IF= 3.607)
17. Ye Li (李晔), Tongtao Yue, Kai Yang*, Xianren Zhang*. Molecular modeling of the relationship between nanoparticle shape anisotropy and endocytosis kinetics. Biomaterials, 2012, 33:4965-4973. (SCI Top, IF = 15.8)
18. Edwin H. Shin, Ye Li (李晔), Umesh Kumar, Hursh V. Sureka, Xianren Zhang, Christine K. Payne*. Membrane potential mediates the cellular binding of nanoparticles. Nanoscale, 2013, 5, 5879.(SCI Top, IF= 6.973)
19. Gaoxing Su, Xiaofei Zhou, Hongyu Zhou, Ye Li (李晔) , Xianren Zhang, Yin Liu, Dapeng Cao*, Bing Yan*, Size-dependent facilitation of cancer cell targeting by proteins adsorbed on nanoparticles. ACS Applied Materials & Interfaces, 2016, 8: 30037-30047. (SCI Top, IF = 7.504)
20. FaLin Tian, Tongtao Yue, Ye Li (李晔), Xianren Zhang*. Computer simulation studies on the interactions between nanoparticles and cell membrane. Science China Chemistry, 2014, 57: 1662-1671. (SCI, IF = 6.356)
21. 毛馨艺,兰芸,张准,张叶卓,金琪,赵美棋,曾子柽,李晔* 木质素单体跨膜转运的技术研究进展 生物技术通报 2024, 40 (10):198-207
22. 张曼,张叶卓,何其邹洪,鄂一岚,李晔* 植物细胞壁结构及成像技术研究进展 生物技术通报, 2023,39(7):19-28
软件著作权
1.李晔,具有跨细胞膜转运能力的纳米药物递送载体的形状设计预测软件,2024SR1272647
2.李晔,高效的纳米药物载体的尺寸设计预测软件V1.0, 2024SR0869524